Omega-CTP-Active PHE

• moisturizing efficacy: Application of 3 % Omega- CTP-Active PHE showed an enhancement of skin hydration of 7.4 % compared to placebo after 4 weeks.
• cell viability: Application of 3 % Omega-CTP-Active PHE showed an enhancement of viability of 8.27 % after 48h compared to reference (100 % viability, PBS) and after 72h viability was even enhanced by 27.69 %.
• cell proliferation: Application of 3 % Omega-CTP- Active PHE showed a significant enhancement in cell proliferation of 12.77 % after 96h compared to untreated control.
• anti-oxidative potential: Application of Omega-CTP- Active PHE showed a dose depending reduction of oxidative cell stress:

1. 0.5 % -> 29.58 %
2. 1.0 % -> 33.68 %
3. 2.0 % -> 42.95 %
4. up to 3.0 % -> 56.83 %

• compared to untreated ROS induced positive control.
• regulating water balance of the skin
• influencing epidermal barrier function
• regeneration of skin (increase of cell metabolism i.e. collagen production)
• skin remodelling

Omega-CTP-Active is a water soluble radical sca- venger to protect the aqueous phase of the skin from environmental impact. It is containing a number of radical scavengers and quenchers, whereby the cop- per tripeptide, mimics the superoxide dismutase activity.
Copper tripeptide is a multifunctional component, which is naturally present in the body (signal and carrier peptide) and is responsible for stimulation of collagen synthesis, anti-inflammatory actions, accelerated wound healing and tissue repair. This is shown in the below graph, developped by Loren Pickart.


The skin remodelling properties of Copper tripeptide can even lead to scar and stretch mark removal.

The amino acids L-Arginine  and L-Proline are important for the water balance of tissue. L-Arginine is metabolized to Ornithin and Urea in the skin and therefore determines the water binding capacity of stratum corneum. In addition L-Arginine is composing and sustaining the epidermal barrier function. By NO production Arginine is regulating hemo- and lymph vascular perfusion and is therefore responsible for the distribution of nutrients and fluids in the skin. L-Proline has the highest water binding capacity of all amino acids known and is a building stone of collagen. Formulations containing Arginine have been tested to have comparable efficacy like Urea containing preparations.

Omega-CTP-Active PHE is suitable for use in high quality cosmetic products like facial creams, facial masks, ampoules, body lotions, after-sun lotions, after shave products and especially for Anti-Ageing products.

Omega-CTP-Active PHE has been developed from Omega-CHS-Activator® by a careful combination of its original components, which has been tested adequately with regard to its toxicology. For this reason there was no need for any toxicological tests on animals in behalf of the new product. Mutagenity (Ames-Test): Omega-CHS-Activator® shows no negative results in the Salmonella Typh- imurium Reverse Mutation Assay. Photo-allergic and photo-toxic effects: UVA exposed photo patch test with the product shows no photo- allergic or photo-toxic effects.

Omega-CTP-Active PHE should be stored in dark at 10°C - 25°C. Shelf life is 60 months in closed original containers.